circRNA basic information
circBase ID: hsa_circ_0000567
Name: hsa_circ_SETD3
Synonym: CircSETD3
Host Gene: SETD3
Genomic location(hg19): chr14:99924615-99932150:-
Genomic location(hg38): chr14:99458278-99465813:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0019087
MONDO name: cholangiocarcinoma
Disease details: Cholangiocarcinoma / CCA
Disease DO ID:
 4947
Disease MeSH ID:
 D018281
Disease NCIt ID:
 C4436
Disease ICD11 ID:
 2110597275
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

CCA tissues; adjacent normal tissues
Cell lines:

HiBECs; HUCCT1; TFK1; QBC939; 293 T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: BMF
Associated microRNA: miR-421
Biological function: inhibits proliferation and induces apoptosis
Molecular mechanism: circSETD3 negatively regulates miR-421, thereby modulating the miR-421/BMF axis to affect apoptosis-related proteins
Biological pathway or process:

proliferation (inhibits); apoptosis (promotes); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Annexin V/PI Flow Cytometry; Western Blot
Clinical significance:

potential as a promising candidate for CCA therapy
Description:

CircSETD3 (hsa_circ_0000567) is down-regulated in cholangiocarcinoma tissues and cell lines. Its overexpression suppresses proliferation and promotes apoptosis, at least partly by negatively regulating miR-421 and affecting the miR-421/BMF axis.
Confidence score:

0.6479
Other information
Title:

CircSETD3 (hsa_circ_0000567) inhibits proliferation and induces apoptosis in cholangiocarcinoma cells via downregulation of microRNA-421 expression.

Journal: Bioengineered
Published: 2022
PubMed ID: 35435120
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -