circRNA basic information
circBase ID: hsa_circ_0113010
Name: hsa_circ_EPB41
Synonym: circEPB41
Host Gene: EPB41
Genomic location(hg19): chr1:29762359-29768827:+
Genomic location(hg38): chr1:29435847-29442315:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002009
MONDO name: major depressive disorder
Disease details: major depressive disorder / MDD
Disease DO ID:
 1470
Disease MeSH ID:
 D003865
Disease NCIt ID:
 C35094
Disease ICD11 ID:
 -
Disease OMIM ID:
 608516
Species: Human
Species details: Homo sapiens
Tissue specimen:

whole blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: DDIT4, S100B, Fbln2
Associated microRNA: hsa-miR-103a-3p, hsa-miR-27a-3p, hsa-miR-200c-3p
Biological function: Potential diagnostic biomarker for MDD; suspected involvement in MDD neuroplasticity.
Molecular mechanism: May affect neuroplasticity through the ceRNA mechanism.
Biological pathway or process:

ceRNA regulation (other); other pathway/process (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Can be used as diagnostic markers for MDD; ROC analysis indicated discrimination between MDD patients and healthy controls.
Description:

hsa_circ_0113010 (also referred to as circEPB41) is up-regulated in peripheral blood of MDD patients and shows diagnostic potential by ROC analysis. Bioinformatics analysis suggests it may be involved in MDD neuroplasticity through a predicted ceRNA mechanism.
Confidence score:

0.5047
Other information
Title:

Peripheral Blood Circular RNAs as a Biomarker for Major Depressive Disorder and Prediction of Possible Pathways.

Journal: Frontiers in neuroscience
Published: 2022
PubMed ID: 35431783
Study type:

combined biological and clinical study
Data availability: GSE190518
Code availability: -