circRNA basic information
circBase ID: hsa_circ_0002473
Name: hsa_circ_DNAJC3
Synonym: -
Host Gene: DNAJC3
Genomic location(hg19): chr13:96375495-96377506:+
Genomic location(hg38): chr13:96375495-96377506:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002009
MONDO name: major depressive disorder
Disease details: major depressive disorder / MDD
Disease DO ID:
 1470
Disease MeSH ID:
 D003865
Disease NCIt ID:
 C35094
Disease ICD11 ID:
 -
Disease OMIM ID:
 608516
Species: Human
Species details: Homo sapiens
Tissue specimen:

whole blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential diagnostic biomarker for MDD; not supported to function via ceRNA network in this study.
Molecular mechanism: No ceRNA relationship pair reported for hsa_circ_0002473.
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Can be used as diagnostic markers for MDD; ROC analysis showed discriminative ability (AUC = 0.8619).
Description:

hsa_circ_0002473 is up-regulated in peripheral blood of MDD patients and shows diagnostic potential by ROC analysis. Unlike the other verified circRNAs, it was reported to have no ceRNA relationship pair in the constructed network.
Confidence score:

0.5047
Other information
Title:

Peripheral Blood Circular RNAs as a Biomarker for Major Depressive Disorder and Prediction of Possible Pathways.

Journal: Frontiers in neuroscience
Published: 2022
PubMed ID: 35431783
Study type:

combined biological and clinical study
Data availability: GSE190518
Code availability: -