circRNA basic information
circBase ID: hsa_circ_0001666
Name: hsa_circ_FAM120B
Synonym: hsa_circ_000742
Host Gene: FAM120B
Genomic location(hg19): chr6:170626457-170639638:+
Genomic location(hg38): chr6:170317369-170330550:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

MCF-10A; MCF-7; BT-20
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Potential diagnostic biomarker for breast cancer; expression decreases from normal breast cells to tumorigenic and metastatic breast cancer cell lines.
Molecular mechanism: Not experimentally determined in this study.
Biological pathway or process:

not specified (other)
Detected method:
Q
Validation methods:

RT-qPCR
Clinical significance:

Potential early diagnostic biomarker for breast cancer; monitoring expression may help early detection and disease progression tracking, but clinical validation is still required.
Description:

hsa_circ_0001666 was experimentally measured by RT-qPCR in MCF-10A, BT-20, and MCF-7 cells and was significantly down-regulated in breast cancer and metastatic cell lines compared with normal breast epithelial cells. The study suggests it may serve as an early diagnostic biomarker for breast cancer, although mechanistic and clinical validation were not performed.
Confidence score:

0.1155
Other information
Title:

Study the Expression of Two Circular RNAs, hsa_circ_0003227 and hsa_circ_0001666, in the Primary Breast Cancer Cell Line BT-20 and the Metastatic Breast Cancer Cell Line MCF-7.

Journal: Biochemical genetics
Published: 2026
PubMed ID: 39976889
Study type:

biological research
Data availability: -
Code availability: -