| Expression pattern: |
UP |
| Associated gene: |
HMGA1, Ago2 |
| Associated microRNA: |
miR-1294 |
| Biological function: |
promotes proliferation, migration, and invasion; suppresses apoptosis; promotes malignant progression of NSCLC |
| Molecular mechanism: |
ceRNA-like mechanism: circPLK1 sponges miR-1294 to upregulate HMGA1 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; ROC Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot |
| Clinical significance: |
High circPLK1 expression is associated with poorer prognosis and has diagnostic/predictive value (AUC 0.866) in NSCLC. |
| Description: |
circPLK1 is upregulated in NSCLC tissues and serum exosomes and promotes NSCLC cell proliferation, migration, and invasion while inhibiting apoptosis. Mechanistically, exosomal circPLK1 functions as a miR-1294 sponge to maintain high HMGA1 expression, forming a circPLK1/miR-1294/HMGA1 regulatory axis. High circPLK1 expression is associated with poor overall survival and shows potential diagnostic value in NSCLC. |
| Confidence score: |
0.7972 |