| Expression pattern: |
UP |
| Associated gene: |
ERC1 / ELKS/RAB6-interacting/CAST family member-1, Ago2 |
| Associated microRNA: |
miR-142-3p |
| Biological function: |
Promotes breast cancer cell proliferation, colony formation, and invasion, and inhibits apoptosis; circ_0084927 knockdown suppresses malignant phenotypes and induces apoptosis. |
| Molecular mechanism: |
circ_0084927 acts as a ceRNA that sponges miR-142-3p, relieving miR-142-3p-mediated repression of ERC1 and thereby promoting breast cancer progression. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Clinical Sample Validation; Cohort Study; Survival Analysis |
| Clinical significance: |
High circ_0084927 expression was correlated with higher TNM stage, more lymph node metastasis, negative PR expression, and poor survival in patients with breast cancer; circ_0084927/miR-142-3p/ERC1 may be a potential therapeutic target for breast cancer. |
| Description: |
circ_0084927 is up-regulated in breast cancer tissues and cell lines, and high expression is associated with poorer survival and adverse clinicopathological features. Functionally, circ_0084927 promotes breast cancer cell proliferation, colony formation, and invasion while suppressing apoptosis. Mechanistically, cytoplasmic circ_0084927 acts as a ceRNA for miR-142-3p to increase ERC1 expression, forming a circ_0084927/miR-142-3p/ERC1 regulatory axis. |
| Confidence score: |
0.835 |