| Expression pattern: |
UP |
| Associated gene: |
PI3K/AKT pathway |
| Associated microRNA: |
hsa-miR-1236, hsa-miR-1244, hsa-miR-383, hsa-miR-587, hsa-miR-622, hsa-miR-634, hsa-miR-665, hsa-miR-766, hsa-miR-942, hsa-miR-143 |
| Biological function: |
May promote proliferation and invasion in breast cancer; suggested as a diagnostic biomarker; associated with estrogen receptor (ER). |
| Molecular mechanism: |
Predicted miRNA sponge mechanism (ceRNA-like), targeting miRNAs involved in PI3K/AKT signaling; discussion suggests inhibition of hsa-miR-383. |
| Biological pathway or process: |
PI3K/AKT (promotes); proliferation (promotes); invasion (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
High expression in BC tissues with diagnostic value by ROC (AUC reported); associated with ER receptor status. |
| Description: |
hsa_circ_0001791 is up-regulated in breast cancer tissues and has strong diagnostic performance by ROC analysis (AUC reported). It is associated with ER status and is proposed (mainly by bioinformatics/discussion) to sponge miR-383 and affect PI3K/AKT signaling, potentially promoting malignant phenotypes. |
| Confidence score: |
0.459 |