| Expression pattern: |
DN |
| Associated gene: |
UPK1A, Ago2 |
| Associated microRNA: |
miR-658 |
| Biological function: |
Suppresses breast cancer cell proliferation and migration/lung metastasis; inhibits tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge/ceRNA for miR-658, competing with UPK1A for miR-658 binding and increasing UPK1A expression (Ago2-RISC involved). |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); metastasis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Colony Formation Assay; In Vivo Animal Model; H&E Staining; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Low levels of circNFIC were related to poor outcome and shorter overall survival in breast cancer. |
| Description: |
circNFIC is down-regulated in breast cancer (especially lung metastatic tissues) and functions as a tumor suppressor. It predominantly localizes to the cytoplasm and acts as a ceRNA by sponging miR-658 to relieve repression of UPK1A, thereby inhibiting proliferation and lung metastasis; low circNFIC is associated with worse survival. |
| Confidence score: |
0.7845 |