circRNA basic information
circBase ID: -
Name: hsa_circ_NFIX
Synonym: circRNA NFIX
Host Gene: NFIX
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue; paracancer tissues
Cell lines:

A549; NCI-H23; BEAS2B; 293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: TRIAP1
Associated microRNA: miRNA-214-3p
Biological function: promotes proliferation; inhibits apoptosis
Molecular mechanism: circRNA NFIX directly binds miRNA-214-3p and modulates the miR-214-3p/TRIAP1 axis, affecting TRIAP1 expression and apoptosis-related proteins.
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; MTT; Annexin V/PI Flow Cytometry; Western Blot; Clinical Sample Validation
Clinical significance:

a potential diagnostic and therapeutic target for NSCLC
Description:

circRNA NFIX is up-regulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA. It sponges miRNA-214-3p to relieve repression of TRIAP1, thereby promoting proliferation and inhibiting apoptosis in NSCLC cells.
Confidence score:

0.6479
Other information
Title:

Circular RNA NFIX Functions as an Oncogene in Non-Small Cell Lung Cancer by Modulating the miR-214-3p/TRIAP1 Axis.

Journal: The clinical respiratory journal
Published: 2024
PubMed ID: 39135128
Study type:

combined biological and clinical study
Data availability: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Code availability: -