| Expression pattern: |
UP |
| Associated gene: |
NT5E |
| Associated microRNA: |
miR-628-5p |
| Biological function: |
Promotes cell proliferation, spheroid formation, invasion, migration and tumor growth; inhibits apoptosis in gastric cancer. |
| Molecular mechanism: |
Acts as a ceRNA by competitively binding miR-628-5p to regulate NT5E expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); invasion (promotes); migration (promotes); apoptosis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Transfection; Luciferase Reporter Assay; RNA Pull-Down; Colony Formation Assay; MTT; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circ_HN1 is up-regulated in gastric cancer and mainly localizes to the cytoplasm. It promotes malignant phenotypes (proliferation, spheroid formation, migration/invasion, tumor growth) and inhibits apoptosis by acting as a ceRNA that sponges miR-628-5p to upregulate NT5E. |
| Confidence score: |
0.8122 |