| Expression pattern: |
DN |
| Associated gene: |
FTO, Ago2 |
| Associated microRNA: |
miR-4739 |
| Biological function: |
inhibits proliferation, colony formation, invasion, tumor growth and lung metastasis |
| Molecular mechanism: |
circGPR137B sponges miR-4739 to upregulate FTO; FTO binds circGPR137B and demethylates m6A to promote circGPR137B expression, forming a positive feedback loop |
| Biological pathway or process: |
proliferation (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (other); m6A modification (other) |
| Detected method: |
Q
H
M
|
| Validation methods: |
Microarray; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; RNase R Treatment; Actinomycin D / DRB Stability Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); MeRIP / MeRIP-seq; Transfection; MTT; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
downregulation of circGPR137B was associated with poor prognosis in patients with HCC |
| Description: |
circGPR137B is down-regulated in HCC and functions as a tumor suppressor. It sponges miR-4739 to relieve repression of FTO, while FTO demethylates circGPR137B (m6A) and enhances circGPR137B expression, forming a positive feedback loop that inhibits proliferation, invasion, and metastasis. |
| Confidence score: |
0.8846 |