| Expression pattern: |
UP |
| Associated gene: |
TGFBR1, Ago2 |
| Associated microRNA: |
miR-337-3p |
| Biological function: |
promotes proliferation, migration, invasion and lung metastasis of cervical cancer cells |
| Molecular mechanism: |
ceRNA mechanism: circ_0000228 sponges miR-337-3p to up-modulate TGFBR1 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
Bioinformatics Analysis; RNA-seq; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; BrdU; Transwell Assay; Western Blot; In Vivo Animal Model; H&E Staining |
| Clinical significance: |
high circ_0000228 expression in the CC tissues was linked to lymph node metastasis and low differentiation of tumor tissues |
| Description: |
circ_0000228 is up-regulated in cervical cancer tissues/cells and acts as an oncogenic circRNA. It promotes proliferation, migration, invasion and lung metastasis by sponging miR-337-3p to increase TGFBR1 expression. |
| Confidence score: |
0.742 |