| Expression pattern: |
UP |
| Associated gene: |
FOXQ1, AGO2 |
| Associated microRNA: |
miR-140-3p |
| Biological function: |
Promotes bladder cancer cell proliferation, migration, invasion, tumorigenesis and metastasis. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge by binding miR-140-3p to modulate FOXQ1 expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; RNase R Treatment; RNA Pull-Down; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; MTT; Wound Healing Assay; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Survival Analysis; Clinical Sample Validation |
| Clinical significance: |
High expression is correlated with clinicopathologic characteristics and overall survival; proposed as diagnostic/prognostic biomarker and therapeutic target. |
| Description: |
hsa_circRNA_0088036 is upregulated in bladder cancer and promotes proliferation, migration, invasion and metastasis. It functions as a ceRNA by sponging miR-140-3p, thereby increasing FOXQ1 expression, and its high expression is associated with worse overall survival and aggressive clinicopathologic features. |
| Confidence score: |
0.8486 |