circRNA basic information
circBase ID: -
Name: hsa_circ_BANP
Synonym: circ-BANP
Host Gene: BANP
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; para-tissues; residual tumors after insufficient RFA
Cell lines:

Huh7; Huh7-H
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: TLR4, STAT3
Associated microRNA: let-7f-5p
Biological function: promotes proliferation, migration, invasion, angiogenesis, and EMT in residual HCC after insufficient RFA
Molecular mechanism: circ-BANP acts as a ceRNA sponging let-7f-5p, thereby relieving repression of TLR4 and activating the TLR4/STAT3 signaling pathway
Biological pathway or process:

JAK/STAT (promotes); EMT (promotes); angiogenesis (promotes); proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Bioinformatics Analysis; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation
Clinical significance:

-
Description:

circ-BANP is up-regulated in HCC (especially residual tumors after insufficient RFA) and promotes malignant behaviors. Mechanistically, it sponges let-7f-5p to de-repress TLR4, activating the TLR4/STAT3 pathway to enhance proliferation, migration/invasion, angiogenesis, and EMT; circ-BANP knockdown suppresses these phenotypes in vitro and in a xenograft model.
Confidence score:

0.7045
Other information
Title:

Circular BANP knockdown inhibits the malignant progression of residual hepatocellular carcinoma after insufficient radiofrequency ablation.

Journal: Chinese medical journal
Published: 2022
PubMed ID: 34985013
Study type:

combined biological and clinical study
Data availability: Supplemental digital content is available for this article.
Code availability: -