| Expression pattern: |
UP |
| Associated gene: |
NACC1, Ago2 |
| Associated microRNA: |
miR-361-3p |
| Biological function: |
promotes proliferation, migration, invasion, stemness, EMT, angiogenesis, and metastasis in HCC |
| Molecular mechanism: |
Exosomal circHDAC1_004 acts as a miRNA sponge for miR-361-3p to upregulate NACC1 and promote EMT and malignant phenotypes. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); angiogenesis (promotes); EMT (promotes); stemness (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Sanger Sequencing; divergent primers PCR; RNase R Treatment; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Survival Analysis; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Tube Formation Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Western Blot; IF (Immunofluorescence); Bioinformatics Analysis |
| Clinical significance: |
High circHDAC1_004 expression is associated with shorter overall survival in HCC patients. |
| Description: |
circHDAC1_004 is up-regulated in HCC and its high expression indicates poorer overall survival. It mainly localizes to the cytoplasm, is transported via exosomes, and promotes HCC proliferation, migration/invasion, stemness, EMT, metastasis, and angiogenesis by sponging miR-361-3p to upregulate NACC1. |
| Confidence score: |
0.8871 |