| Expression pattern: |
DN |
| Associated gene: |
CNBP, SLC38A1 |
| Associated microRNA: |
- |
| Biological function: |
repressed cell proliferation, migration, invasion; halted G1/S transition; tumor suppressor in melanoma cells |
| Molecular mechanism: |
circTADA2A binds CNBP and inhibits CNBP trans-activation of SLC38A1 by suppressing CNBP binding to the SLC38A1 promoter, thereby restraining SLC38A1 transcription |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); cell cycle (inhibits); other pathway/process (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Sanger Sequencing; divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; EdU Staining; Colony Formation Assay; CCK8; Transwell Assay; Wound Healing Assay; Cell Cycle Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circTADA2A (hsa_circ_0043278) is down-regulated in melanoma cell lines and mainly localized in the nucleus. It suppresses melanoma cell proliferation, migration, invasion and G1/S transition by binding CNBP and preventing CNBP-mediated transactivation of SLC38A1, thereby reducing SLC38A1 transcription. |
| Confidence score: |
0.8165 |