| Expression pattern: |
DN |
| Associated gene: |
SOX15, active beta-catenin, c-Myc, Wnt2b/beta-catenin pathway |
| Associated microRNA: |
miR-452-5p |
| Biological function: |
Inhibits HCC proliferation, migration, invasion, EMT, tumor stemness, tumor growth, and lenvatinib resistance; enhances apoptosis and lenvatinib sensitivity. |
| Molecular mechanism: |
circPIK3C3 acts as a ceRNA to sponge miR-452-5p, increases SOX15 expression, and suppresses the Wnt/beta-catenin pathway and c-Myc, thereby inhibiting HCC progression and lenvatinib resistance. |
| Biological pathway or process: |
Wnt/beta-catenin (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); EMT (inhibits); stemness (inhibits); apoptosis (promotes); drug resistance (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Wound Healing Assay; TUNEL; Western Blot; RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; In Vivo Animal Model; ISH (In Situ Hybridization); IHC (Immunohistochemistry) |
| Clinical significance: |
circPIK3C3 is linked to HCC patient outcomes, higher expression predicts better prognosis, and it may serve as a prognostic biomarker and marker for forecasting lenvatinib resistance. |
| Description: |
circPIK3C3 is a human PIK3C3-derived circRNA that is down-regulated in HCC tissues, HCC cells, and lenvatinib-resistant HCC cells. It suppresses HCC progression and lenvatinib resistance by sponging miR-452-5p, increasing SOX15 expression, and inhibiting Wnt/beta-catenin signaling. Higher circPIK3C3 expression is associated with better OS and RFS, supporting its potential as a prognostic biomarker and marker of lenvatinib response. |
| Confidence score: |
0.8981 |