| Expression pattern: |
UP |
| Associated gene: |
PTN / pleiotrophin |
| Associated microRNA: |
miR-137-3p |
| Biological function: |
circ-LDLRAD3 promotes pancreatic cancer cell proliferation, migration, invasion and xenograft tumor growth; knockdown suppresses pancreatic cancer progression in vitro and in vivo. |
| Molecular mechanism: |
circ-LDLRAD3 acts as a ceRNA/miRNA sponge for miR-137-3p to regulate PTN expression, thereby promoting pancreatic cancer progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Increased expression of circ-LDLRAD3 was indicative of a poor prognosis in patients with pancreatic cancer. |
| Description: |
circ-LDLRAD3 is up-regulated in pancreatic cancer tissues and cell lines, and high expression is associated with poor overall survival. Functionally, circ-LDLRAD3 promotes pancreatic cancer cell proliferation, migration, invasion and xenograft tumor growth by sponging miR-137-3p and regulating PTN expression. |
| Confidence score: |
0.8005 |