circRNA basic information
circBase ID: hsa_circ_0005777
Name: hsa_circ_ARHGEF28
Synonym: circARHGEF28
Host Gene: ARHGEF28
Genomic location(hg19): chr5:73136304-73136585:+
Genomic location(hg38): chr5:73840479-73840760:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005076
MONDO name: periodontitis
Disease details: periodontitis
Disease DO ID:
 824, 9893
Disease MeSH ID:
 D010518
Disease NCIt ID:
 C34918
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

gingival tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential biomarker for periodontitis diagnosis; expression positively correlates with probing depth (PD); predicted involvement in immune response, apoptosis, migration and adhesion, and oxidative stress-related processes.
Molecular mechanism: Predicted circRNA-miRNA-mRNA regulatory network (ceRNA) in periodontitis (bioinformatics prediction; not experimentally validated).
Biological pathway or process:

immune regulation (other); apoptosis (other); migration (other); adhesion (other); inflammation (other); ceRNA regulation (other); other pathway/process (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; divergent primers PCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Higher expression correlates positively with probing depth (PD) and shows potential diagnostic value in periodontitis (ROC AUC=0.8244).
Description:

circARHGEF28 is significantly up-regulated in periodontitis gingival tissues, correlates positively with probing depth, and shows potential diagnostic value (ROC AUC 0.8244). It is part of a predicted circRNA-miRNA-mRNA network suggesting involvement in immune/inflammatory response and other periodontitis-related biological processes, but specific miRNA/mRNA axes were not experimentally validated.
Confidence score:

0.5963
Other information
Title:

Identification of potentially functional circRNAs and prediction of circRNA-miRNA-mRNA regulatory network in periodontitis: Bridging the gap between bioinformatics and clinical needs.

Journal: Journal of periodontal research
Published: 2022
PubMed ID: 35388494
Study type:

combined biological and clinical study
Data availability: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Code availability: -