| Expression pattern: |
DN |
| Associated gene: |
NF-kappaB, NLRP3 |
| Associated microRNA: |
- |
| Biological function: |
alleviates LPS-induced chondrocyte injury by promoting proliferation and inhibiting apoptosis, inflammation, and extracellular matrix degradation |
| Molecular mechanism: |
inhibits LPS-induced NF-kappaB activation and downstream NLRP3 inflammasome activation; NLRP3 activation reverses the protective effects of circSFMBT2-OA |
| Biological pathway or process: |
NF-kappaB (inhibits); inflammation (inhibits); apoptosis (inhibits); proliferation (promotes); other pathway/process (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Sanger Sequencing; divergent primers PCR; RNase R Treatment; FISH / smFISH; Transfection; CCK8; EdU Staining; TUNEL; Western Blot; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
provides a promising target to treat OA |
| Description: |
circSFMBT2-OA (has_circ_0017636), a SFMBT2-derived circRNA, is decreased in osteoarthritis cartilage. Its overexpression protects LPS-injured chondrocytes by promoting proliferation and inhibiting apoptosis, inflammatory cytokine production, and ECM degradation, at least partly via suppressing NF-kappaB/NLRP3 inflammasome activation. |
| Confidence score: |
0.7507 |