| Expression pattern: |
DN |
| Associated gene: |
MMP2, MMP9, VEGF |
| Associated microRNA: |
miR-19a |
| Biological function: |
Tumor suppressive role in pancreatic adenocarcinoma cells by inhibiting proliferation, migration, and invasion. |
| Molecular mechanism: |
Circ-MYBL2 decreases miR-19a accumulation by increasing methylation of the miR-19a RNA gene/promoter region, thereby suppressing malignant phenotypes. |
| Biological pathway or process: |
m6A modification (not specified); proliferation (inhibits); migration (inhibits); invasion (inhibits); mRNA stability (not specified); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MSP (Methylation-Specific PCR); BrdU; Transwell Assay; Wound Healing Assay; Western Blot |
| Clinical significance: |
- |
| Description: |
Circ-MYBL2 is downregulated in pancreatic adenocarcinoma tissues and acts as a tumor suppressor in PA cells. Its overexpression reduces proliferation and motility by decreasing miR-19a levels, likely via increased methylation of the miR-19a RNA gene/promoter. |
| Confidence score: |
0.6261 |