circRNA basic information
circBase ID: hsa_circ_0014188
Name: hsa_circ_SNX27
Synonym: circ-SNX27
Host Gene: SNX27
Genomic location(hg19): chr1:151611363-151665959:+
Genomic location(hg38): chr1:151638887-151693483:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tumoral tissue; adjacent normal tissues
Cell lines:

Hep 3B; Huh7; MHCC-97H; SNU-182; THLE-2
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: RPN1, Ago2
Associated microRNA: miR-375
Biological function: promotes proliferation and invasion; inhibits apoptosis; promotes tumor growth
Molecular mechanism: Circ-SNX27 acts as a miRNA sponge to competitively bind miR-375 and thereby enhances RPN1 expression.
Biological pathway or process:

proliferation (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Transwell Assay; In Vivo Animal Model; Western Blot
Clinical significance:

-
Description:

circ-SNX27 is up-regulated in HCC tissues and cell lines and functions as an oncogenic circRNA. It mainly localizes to the cytoplasm, sponges miR-375, and thereby upregulates RPN1, promoting proliferation and invasion while inhibiting apoptosis and enhancing xenograft tumor growth.
Confidence score:

0.6996
Other information
Title:

Circ-SNX27 sponging miR-375/RPN1 axis contributes to hepatocellular carcinoma progression.

Journal: The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology
Published: 2023
PubMed ID: 37386831
Study type:

combined biological and clinical study
Data availability: Supplementary data including one figure can be found with this article online at https://doi.org/10.4196/kjpp.2023.27.4.333.
Code availability: -