circRNA basic information
circBase ID: hsa_circ_0072088
Name: -
Synonym: hsa_circRNA_103809
Host Gene: -
Genomic location(hg19): chr5:32379220-32388780:-
Genomic location(hg38): chr5:32379114-32388674:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

LUAD tissues; adjacent normal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: TMEM52, IL24, POF1B, KIF1A, NHS, LBH, HIST2H2BE, ABCC3, PYCR1, CD79A, IGF2BP3, ANKRD17, GTSE1, MKI67, CLSPN, PLAU, LUC7L, MAGIX, GPATCH4, ABAT
Associated microRNA: hsa-miR-532-3p, hsa-miR-942, hsa-miR-942-5p
Biological function: unknown
Molecular mechanism: ceRNA network via sponging miRNAs (hsa-miR-532-3p; hsa-miR-942-5p) to regulate downstream mRNAs
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

hsa_circ_0072088 may serve as a prognostic marker in LUAD
Description:

hsa_circ_0072088 is up-regulated in LUAD tissues versus adjacent normal tissues (microarray and qRT-PCR). The study constructed a predicted ceRNA network in which hsa_circ_0072088 may sponge hsa-miR-532-3p and hsa-miR-942-5p to influence multiple downstream mRNAs (including IGF2BP3, MKI67, CD79A, and ABAT).
Confidence score:

0.4032
Other information
Title:

Construction and Analysis of a circRNA-Mediated ceRNA Network in Lung Adenocarcinoma.

Journal: OncoTargets and therapy
Published: 2021
PubMed ID: 34135596
Study type:

combined biological and clinical study
Data availability: GSE101684; GSE101586; GSE135918; GSE130779
Code availability: -