circRNA basic information
circBase ID: hsa_circ_0067934
Name: -
Synonym: circ_0067934 / circ-0067934
Host Gene: -
Genomic location(hg19): chr3:170013698-170015181:+
Genomic location(hg38): chr3:170295910-170297393:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

GES-1; AGS; MKN-45
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: KIF23
Associated microRNA: miR-1301-3p
Biological function: promotes gastric cancer cell proliferation, migration and invasion
Molecular mechanism: circ_0067934 acts as a miRNA sponge for miR-1301-3p to regulate KIF23 expression
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; CCK8; EdU Staining; Wound Healing Assay; Transwell Assay; Western Blot
Clinical significance:

-
Description:

circ_0067934 is upregulated in gastric cancer cell lines and functions as a pro-tumor circRNA by promoting proliferation, migration and invasion. Mechanistically, it sponges miR-1301-3p to relieve repression of KIF23, forming a circ_0067934/miR-1301-3p/KIF23 axis.
Confidence score:

0.5997
Other information
Title:

Knockdown of circ_0067934 inhibits gastric cancer cell proliferation, migration and invasion via the miR‑1301‑3p/KIF23 axis.

Journal: Molecular medicine reports
Published: 2022
PubMed ID: 35475447
Study type:

biological research
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -