circRNA basic information
circBase ID: hsa_circ_0062019
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr21:46934628-46952062:-
Genomic location(hg38): chr21:45514714-45532148:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: prostate cancer
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HPrEpiC; PC3; DU145; LNCaP; 22RV1; HEK-293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: HMGA2 / high mobility group AT-hook 2
Associated microRNA: miR-195-5p
Biological function: Promotes prostate cancer cell proliferation, migration, and invasion.
Molecular mechanism: hsa_circ_0062019 acts as a miR-195-5p sponge to upregulate HMGA2 expression, thereby promoting malignant phenotypes in prostate cancer cells.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

Potential target for the treatment of prostate cancer.
Description:

hsa_circ_0062019 is up-regulated in prostate cancer cell lines and promotes proliferation, migration, and invasion. Mechanistically, it sponges miR-195-5p to increase HMGA2 expression, and HMGA2 knockdown reverses the hsa_circ_0062019-induced malignant phenotypes.
Confidence score:

0.5554
Other information
Title:

hsa_circ_0062019 promotes the proliferation, migration, and invasion of prostate cancer cells via the miR-195-5p/HMGA2 axis.

Journal: Acta biochimica et biophysica Sinica
Published: 2021
PubMed ID: 33978716
Study type:

biological research
Data availability: -
Code availability: -