circRNA basic information
circBase ID: hsa_circ_0000376
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr12:11199618-11248400:-
Genomic location(hg38): chr12:11047019-11095801:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

breast cancer tissue samples; normal mammary gland tissue samples; nontumor breast samples; luminal A breast cancer samples; TNBC samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: SMURF1, BTRC, TP53
Associated microRNA: miR-1285-3p, miR-1286
Biological function: regulates tumorigenesis; regulates cell proliferation; regulates metastasis
Molecular mechanism: ceRNA (miRNA sponge) mechanism targeting miR-1285-3p and regulating downstream target genes (e.g., SMURF1, BTRC, TP53)
Biological pathway or process:

ceRNA regulation (other); apoptosis (other); cell cycle (other); metastasis (other); Wnt/beta-catenin (other); ubiquitination (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

-
Description:

This study identifies hsa_circ_0000376 as a down-regulated circRNA in breast cancer based on the GSE101123 circRNA microarray. Bioinformatic analyses suggest it may function as a ceRNA by sponging miR-1285-3p (and miR-1286), thereby affecting downstream targets such as SMURF1, BTRC, and TP53 and influencing tumorigenesis-related processes including proliferation and metastasis.
Confidence score:

0.1768
Other information
Title:

Circular RNA hsa_circ_0000376 Participates in Tumorigenesis of Breast Cancer by Targeting miR-1285-3p.

Journal: Technology in cancer research & treatment
Published: 2020
PubMed ID: 32462972
Study type:

combined biological and clinical study
Data availability: GSE101123
Code availability: -