| Expression pattern: |
DN |
| Associated gene: |
TMEM100, SETD3 |
| Associated microRNA: |
miR-421 |
| Biological function: |
Suppresses LUAD cell migration and invasion. |
| Molecular mechanism: |
Acts as a miR-421 sponge (ceRNA), relieving miR-421-mediated suppression of TMEM100. |
| Biological pathway or process: |
migration (inhibits); invasion (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Transfection; Luciferase Reporter Assay; Transwell Assay; Wound Healing Assay; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
Low circ_0000567 and high miR-421 expression are associated with LUAD; circ_0000567/miR-421/TMEM100 axis is linked to prognosis (OS). |
| Description: |
circ_0000567 is down-regulated in LUAD tissues and cell lines. Functionally, circ_0000567 suppresses LUAD cell migration and invasion by sponging miR-421, thereby relieving miR-421-mediated repression of TMEM100 in a ceRNA network. |
| Confidence score: |
0.704 |