| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
let-7g |
| Biological function: |
Serves as a serum exosomal diagnostic biomarker for NSCLC and early-stage NSCLC; distinguishes NSCLC cases from healthy controls and COPD controls. |
| Molecular mechanism: |
Exosomal circRNA biomarker; potential miRNA-binding mechanism was predicted, but the functional mechanism is unknown. |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
circ_0047921 showed diagnostic value for distinguishing NSCLC patients from healthy controls, early-stage NSCLC from healthy controls, and NSCLC from COPD controls; the three-circRNA panel showed high diagnostic accuracy. |
| Description: |
circ_0047921 is a down-regulated serum exosomal circRNA in NSCLC. It was validated by qPCR and splice-junction sequencing and showed diagnostic utility for NSCLC, including early-stage disease and discrimination from COPD controls; a predicted miRNA interaction with let-7g was noted. |
| Confidence score: |
0.6556 |