| Expression pattern: |
UP |
| Associated gene: |
HMGA2 |
| Associated microRNA: |
miR-205-5p |
| Biological function: |
promotes viability, colony formation, migration, invasion, EMT-like changes, and tumor growth in CRC; knockdown suppresses these phenotypes |
| Molecular mechanism: |
ceRNA mechanism: circ_0007331 sponges miR-205-5p to regulate HMGA2 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (promotes); metastasis (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
circ_0007331 may be a potential biomarker for CRC |
| Description: |
circ_0007331 is up-regulated in colorectal cancer and promotes CRC cell growth, colony formation, migration and invasion, and tumor growth in vivo. Mechanistically, it acts through a circ_0007331/miR-205-5p/HMGA2 ceRNA axis, where circ_0007331 suppresses miR-205-5p to increase HMGA2, contributing to EMT-associated changes. |
| Confidence score: |
0.7094 |