circRNA basic information
circBase ID: hsa_circ_0119816
Name: hsa_circ_BIRC6
Synonym: circBIRC6 / circ_0119816
Host Gene: BIRC6
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: Prostate cancer / PCa
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

prostate cancer; prostate hyperplasia
Cell lines:

RWPE-1; 22RV1; C4-2; PC-3; DU145
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: DNAJB1, AGO2
Associated microRNA: miR-574-5p
Biological function: promotes proliferation, invasion, EMT and autophagy and inhibits apoptosis in prostate cancer cells
Molecular mechanism: ceRNA mechanism: CircBIRC6 interacts with miR-574-5p and regulates DNAJB1 expression
Biological pathway or process:

proliferation (promotes); invasion (promotes); EMT (promotes); autophagy (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; IF (Immunofluorescence); Western Blot; Cell Cycle Assay
Clinical significance:

-
Description:

CircBIRC6 (hsa_circ_0119816) is up-regulated in prostate cancer and mainly localizes to the cytoplasm. It promotes malignant phenotypes (proliferation, invasion, EMT, and autophagy) and inhibits apoptosis, at least partly through the circBIRC6/miR-574-5p/DNAJB1 regulatory axis.
Confidence score:

0.7449
Other information
Title:

CircBIRC6 affects prostate cancer progression by regulating miR-574-5p and DNAJB1.

Journal: Cancer biology & therapy
Published: 2024
PubMed ID: 39258752
Study type:

combined biological and clinical study
Data availability: Data sets generated and/or analyzed during the current study are available from the corresponding author upon reasonable request.; Supplemental data for this article can be accessed online at https://doi.org/10.1080/15384047.2024.2399363
Code availability: -