| Expression pattern: |
DN |
| Associated gene: |
SORCS1, CUBN, AGO2 |
| Associated microRNA: |
miR-431-5p |
| Biological function: |
Suppresses cell viability and colony formation, promotes apoptosis, and inhibits tumor growth (tumour suppressor) in CADC. |
| Molecular mechanism: |
ceRNA/miRNA sponge: circSPIDR binds miR-431-5p to de-repress and upregulate SORCS1 and CUBN. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (inhibits); apoptosis (promotes) |
| Detected method: |
Q
B
S
|
| Validation methods: |
RNA-seq; RT-qPCR; RNase R Treatment; Northern Blot; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); FISH / smFISH; Transfection; CCK8; Colony Formation Assay; BrdU; Annexin V/PI Flow Cytometry; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining; ROC Analysis; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
circSPIDR is down-regulated in CADC tissues and shows diagnostic potential (AUC 0.794); expression correlates negatively with miR-431-5p and positively with SORCS1 and CUBN in clinical samples. |
| Description: |
circSPIDR is down-regulated in cervical adenocarcinoma and functions as a tumour suppressor. It sponges miR-431-5p to de-repress SORCS1 and CUBN, thereby inhibiting proliferation/colony formation and promoting apoptosis, and it suppresses tumour growth in xenograft models. Clinically, circSPIDR shows diagnostic potential by ROC analysis and correlates with miR-431-5p/SORCS1/CUBN expression in patient tissues. |
| Confidence score: |
0.8792 |