| Expression pattern: |
UN |
| Associated gene: |
RPS6KA2, AGO2 |
| Associated microRNA: |
miR-106a-5p, miR-519d-3p |
| Biological function: |
Inhibits ovarian cancer cell proliferation and cell viability. |
| Molecular mechanism: |
Acts as a ceRNA (miRNA sponge) for miR-106a-5p and miR-519d-3p to facilitate RPS6KA2 expression; associated with p38/MAPK signaling. |
| Biological pathway or process: |
proliferation (inhibits); p38 signaling (promotes); MAPK (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Actinomycin D / DRB Stability Assay; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
circFAM169A suppresses ovarian cancer cell proliferation by acting as a cytoplasmic ceRNA that sponges miR-106a-5p and miR-519d-3p, thereby increasing RPS6KA2 expression and affecting p38/MAPK signaling. |
| Confidence score: |
0.7094 |