| Expression pattern: |
UP |
| Associated gene: |
Ras, Raf, MEK, ERK, JAK1, STAT3 |
| Associated microRNA: |
miR-205 |
| Biological function: |
circ-ZNF652 exhibits oncogenic function in renal carcinoma by promoting renal carcinoma cell proliferation and EMT process and inhibiting apoptosis; silencing circ-ZNF652 represses proliferation and EMT process but promotes apoptosis. |
| Molecular mechanism: |
Silencing circ-ZNF652 suppresses Ras/Raf/MEK/ERK and JAK1/STAT3 pathways and raises miR-205 expression; miR-205 functions as a downstream factor mediating effects on proliferation, apoptosis and EMT. |
| Biological pathway or process: |
ERK (promotes); JAK/STAT (promotes); proliferation (promotes); apoptosis (inhibits); EMT (promotes); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; BrdU; Annexin V/PI Flow Cytometry; Western Blot |
| Clinical significance: |
- |
| Description: |
circ-ZNF652 is up-regulated in renal carcinoma tissues and functions as an oncogenic circRNA. Silencing circ-ZNF652 inhibits proliferation and EMT while promoting apoptosis in A498 and ACHN renal carcinoma cells, partly through suppression of Ras/Raf/MEK/ERK and JAK1/STAT3 pathways and up-regulation of miR-205. |
| Confidence score: |
0.5358 |