| Expression pattern: |
UP |
| Associated gene: |
ARRDC3, FAM98A, LAMC1, FOXO3, DICER1, CCND2, IGF1R, TNRC6B |
| Associated microRNA: |
hsa-miR-1184, hsa-miR-153-3p, hsa-miR-548b-3p, hsa-miR-1265, hsa-miR-450b-3p, hsa-miR-182-5p |
| Biological function: |
promotes VSMC phenotypic modulation; promotes migration; promotes proliferation |
| Molecular mechanism: |
predicted miRNA sponge (ceRNA) with circRNA-miRNA-mRNA network; downstream targets not experimentally validated |
| Biological pathway or process: |
PI3K/AKT (other); EGFR (other); proliferation (promotes); migration (promotes); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; RNase R Treatment; RT-qPCR; divergent primers PCR; Sanger Sequencing; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Transfection; Western Blot; Wound Healing Assay; CCK8; Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
hsa_circ_0031608 is up-regulated in ruptured intracranial aneurysm tissues and increases during TNF-alpha-induced VSMC phenotypic transformation. Overexpression promotes a pro-inflammatory VSMC phenotype (↓alpha-SMA/calponin, ↑MMP-2) and enhances VSMC migration and proliferation, with a predicted (but not experimentally validated) circRNA-miRNA-mRNA ceRNA network. |
| Confidence score: |
0.7571 |