circRNA basic information
circBase ID: -
Name: hsa_circ_ZFR
Synonym: -
Host Gene: ZFR
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

BC tissues; adjacent normal tissues; normal mammary gland tissues; tumor tissue
Cell lines:

MCF-7; MDA-MB-231; BT-549; T-47D; MCF-10A
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: FABP7
Associated microRNA: miR-223-3p
Biological function: Promotes breast cancer cell proliferation, migration, invasion, and EMT, and inhibits apoptosis; promotes tumor growth in vivo.
Molecular mechanism: Acts as a miRNA sponge (ceRNA) for miR-223-3p to regulate FABP7 expression.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; RNase R Treatment; Clinical Sample Validation; Bioinformatics Analysis; Transfection; Colony Formation Assay; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; In Vivo Animal Model
Clinical significance:

-
Description:

circ_ZFR is up-regulated in breast cancer tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion, EMT) while inhibiting apoptosis. Mechanistically, it functions as a ceRNA by sponging miR-223-3p to derepress FABP7, thereby enhancing tumor growth in vitro and in a cell line-derived xenograft model.
Confidence score:

0.742
Other information
Title:

Circ_ZFR affects FABP7 expression to regulate breast cancer progression by acting as a sponge for miR-223-3p.

Journal: Thoracic cancer
Published: 2022
PubMed ID: 35355424
Study type:

combined biological and clinical study
Data availability: GSE101124; GSE62931
Code availability: -