| Expression pattern: |
UP |
| Associated gene: |
SRSF1 |
| Associated microRNA: |
- |
| Biological function: |
Promotes HCC cell proliferation, migration, invasion, EMT, and xenograft tumor growth. |
| Molecular mechanism: |
Binds SRSF1 mRNA 3′-UTR and increases SRSF1 mRNA stability, leading to increased SRSF1 expression; SRSF1 mediates the pro-malignant effects. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); mRNA stability (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; Survival Analysis; Transfection; CCK8; Transwell Assay; Wound Healing Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Actinomycin D / DRB Stability Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
High hsa_circRNA_002178 level is associated with lower overall survival and it may serve as a diagnostic marker for HCC. |
| Description: |
In HCC, hsa_circRNA_002178 is up-regulated and promotes proliferation, migration, invasion, EMT, and xenograft tumor growth. Mechanistically, it binds the SRSF1 mRNA 3′-UTR and increases SRSF1 mRNA stability and expression, and SRSF1 mediates the malignant phenotypes. High hsa_circRNA_002178 is linked to poorer overall survival and suggested as a diagnostic marker. |
| Confidence score: |
0.8322 |