circRNA basic information
circBase ID: -
Name: hsa_circ_RNF13
Synonym: circRNF13
Host Gene: RNF13
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009831
MONDO name: malignant pancreatic neoplasm
Disease details: pancreatic cancer
Disease DO ID:
 1793
Disease MeSH ID:
 -
Disease NCIt ID:
 C9005
Disease ICD11 ID:
 542147910
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

pancreatic cancer tissues
Cell lines:

HPDE; PANC-1; MIA-PaCa-2; SW1990; BxPC-3; AsPC-1
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: IGF1R
Associated microRNA: miR-139-5p
Biological function: promotes proliferation, migration, and invasion of pancreatic cancer cells
Molecular mechanism: acts as a molecular sponge of miR-139-5p to relieve repression of IGF1R (ceRNA)
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; FISH / smFISH; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; CCK8; EdU Staining; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation
Clinical significance:

-
Description:

circRNF13 is up-regulated in pancreatic cancer tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion). Mechanistically, circRNF13 mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-139-5p to increase IGF1R expression, thereby driving pancreatic cancer progression.
Confidence score:

0.7859
Other information
Title:

CircRNF13 Promotes the Malignant Progression of Pancreatic Cancer through Targeting miR-139-5p/IGF1R Axis.

Journal: Journal of oncology
Published: 2021
PubMed ID: 34899908
Study type:

combined biological and clinical study
Data availability: All data generated and analyzed during this study are included in this published article and are available on request.
Code availability: -