circRNA basic information
circBase ID: hsa_circ_0089105
Name: hsa_circ_ASS1
Synonym: circASS1
Host Gene: ASS1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: nucleus and cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

MCF-7; MDA-MB-231
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: ASS1
Associated microRNA: miR-4443
Biological function: suppresses invasion and migration of breast cancer cells
Molecular mechanism: circASS1 acts as a miR-4443 sponge and regulates/upregulates its parental gene ASS1 expression
Biological pathway or process:

migration (inhibits); invasion (inhibits); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; Microarray; FISH / smFISH; Transfection; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

-
Description:

circASS1 is down-regulated in the more aggressive breast cancer cell line MDA-MB-231 compared with MCF-7. Functionally, circASS1 suppresses breast cancer cell invasion and migration, likely through sponging miR-4443 and upregulating its parental gene ASS1.
Confidence score:

0.7519
Other information
Title:

Circular RNA circASS1 is downregulated in breast cancer cells MDA-MB-231 and suppressed invasion and migration.

Journal: Epigenomics
Published: 2019
PubMed ID: 30657346
Study type:

biological research
Data availability: Supplementary data at www.futuremedicine.com/doi/full/10.2217/epi-2017-0167
Code availability: -