| Expression pattern: |
UP |
| Associated gene: |
SPOCK1 |
| Associated microRNA: |
miR-30a-3p |
| Biological function: |
Promotes proliferation, suppresses apoptosis, enhances blood-brain barrier penetration and brain metastasis-related invasive features in NSCLC cells; exosomal circ_PPAPDC1A may serve as a diagnostic and prognostic biomarker for NSCLC with brain metastasis. |
| Molecular mechanism: |
circ_PPAPDC1A functions as a miR-30a-3p sponge, relieving miR-30a-3p-mediated repression of SPOCK1 and thereby activating/upregulating SPOCK1. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes); drug resistance (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
Exosomal circ_PPAPDC1A showed diagnostic value for brain metastasis in NSCLC (AUC = 0.8346) and higher expression was associated with shorter progression-free survival and brain metastasis-free survival. |
| Description: |
circ_PPAPDC1A is upregulated in circulating exosomes from NSCLC patients with brain metastasis and in brain-metastatic NSCLC cell lines. It promotes proliferation, suppresses apoptosis, and enhances BBB penetration in vitro by sponging miR-30a-3p and upregulating SPOCK1. Its exosomal expression has potential diagnostic and prognostic value for NSCLC brain metastasis. |
| Confidence score: |
0.7878 |