| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-138-5p, hsa-miR-328-3p |
| Biological function: |
promotes hypoxia-induced PASMC proliferation, cell-cycle progression, migration, and anti-apoptosis |
| Molecular mechanism: |
ceRNA/miRNA sponge mechanism: circWDR37 directly binds (sponges) miR-138 |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); migration (promotes); apoptosis (inhibits); immune regulation (other); inflammation (other); PI3K/AKT (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; divergent primers PCR; Transfection; EdU Staining; CCK8; Wound Healing Assay; TUNEL; Cell Cycle Assay; Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
circWDR37 showed the most significant upregulation in PAH-COPD patients with the higher predictive power |
| Description: |
In PAH/hypoxia-exposed human PASMCs, circWDR37 (hsa_circWDR37_016) is up-regulated and promotes proliferation, cell-cycle progression, migration, and resistance to apoptosis. Mechanistically, it acts as a miRNA sponge by directly binding hsa-miR-138-5p, supporting a circWDR37/miR-138 regulatory module implicated in immunoregulatory/inflammatory processes. |
| Confidence score: |
0.6435 |