circRNA basic information
circBase ID: hsa_circ_0004846
Name: hsa_circ_SAMD4A
Synonym: circSAMD4A
Host Gene: SAMD4A
Genomic location(hg19): chr14:55168779-55169298:+
Genomic location(hg38): chr14:54702061-54702580:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005180
MONDO name: Parkinson disease
Disease details: Parkinson's disease
Disease DO ID:
 14330
Disease MeSH ID:
 D010300
Disease NCIt ID:
 C26845
Disease ICD11 ID:
 296066191
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

midbrain tissues
Cell lines:

SH-SY5Y; 293
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
UP
Associated gene: AMPK, mTOR
Associated microRNA: miR-29c-3p
Biological function: Promotes apoptosis and autophagy in PD models (circSAMD4A knockdown inhibits MPTP/MPP+-induced apoptosis and autophagy).
Molecular mechanism: circSAMD4A directly targets and negatively regulates miR-29c-3p, affecting the AMPK/mTOR cascade (ceRNA-like miRNA sponge mechanism supported by luciferase assays and inhibitor rescue).
Biological pathway or process:

apoptosis (promotes); autophagy (promotes); AMPK (promotes); PI3K/AKT/mTOR (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Luciferase Reporter Assay; Transfection; Western Blot; TUNEL; Annexin V/PI Flow Cytometry; In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

May be a useful diagnostic biomarker and therapeutic target for PD.
Description:

circSAMD4A is upregulated in PD models and promotes dopaminergic neuron apoptosis and autophagy. Mechanistically, circSAMD4A directly targets and negatively regulates miR-29c-3p, thereby modulating the AMPK/mTOR signaling cascade; circSAMD4A knockdown is protective and this protection is reversed by a miR-29c-3p inhibitor.
Confidence score:

0.5607
Other information
Title:

circSAMD4A participates in the apoptosis and autophagy of dopaminergic neurons via the miR‑29c‑3p‑mediated AMPK/mTOR pathway in Parkinson's disease.

Journal: Molecular medicine reports
Published: 2021
PubMed ID: 34080649
Study type:

biological research
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -