circRNA basic information
circBase ID: hsa_circ_0001666
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr6:170626457-170639638:+
Genomic location(hg38): chr6:170317369-170330550:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma / LUAD
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

LAC tissues; adjacent non-cancerous tissues; adjacent normal tissue
Cell lines:

H1299; H1975
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: KIF2C, KIF18B, MELK, BIRC5, PLK1, CKAP2L
Associated microRNA: miR-520f, miR-1261, miR-1270, miR-620, miR-188-3p, miR-516b, miR-940, miR-661
Biological function: Promotes proliferation, migration and invasion in LAC cells.
Molecular mechanism: May act as a miRNA sponge within a circRNA-miRNA-mRNA (ceRNA) network to regulate hub genes (e.g., miR-940/KIF18B, miR-940/CKAP2L, miR-661/CKAP2L, miR-188-3p/PLK1).
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; divergent primers PCR; RNase R Treatment; Sanger Sequencing; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Transfection; CCK8; Transwell Assay
Clinical significance:

Higher expression level indicates poorer prognosis in patients with LAC.
Description:

hsa_circ_0001666 is up-regulated in lung adenocarcinoma and higher expression is associated with poorer prognosis. Knockdown inhibits LAC cell proliferation, migration, and invasion, and network analysis suggests potential ceRNA regulation of hub genes via miR-940 and miR-661 (e.g., KIF18B, CKAP2L) and miR-188-3p (PLK1).
Confidence score:

0.7842
Other information
Title:

Identification of potential circular RNA biomarkers in lung adenocarcinoma: A bioinformatics analysis and retrospective clinical study.

Journal: Oncology letters
Published: 2022
PubMed ID: 35340554
Study type:

combined biological and clinical study
Data availability: GSE101586; TCGA; GEPIA
Code availability: -