| Expression pattern: |
UP |
| Associated gene: |
SLC7A11 |
| Associated microRNA: |
miR-27a-3p |
| Biological function: |
CircBCAR3 supports JVM-2 cell viability and survival, inhibits apoptosis, and inhibits ferroptosis-associated peroxidative damage. |
| Molecular mechanism: |
CircBCAR3 sponges miR-27a-3p and positively regulates SLC7A11 expression, forming a circBCAR3-miR-27a-3p-SLC7A11 axis that inhibits ferroptosis and peroxidative damage. |
| Biological pathway or process: |
ferroptosis (inhibits); apoptosis (inhibits); proliferation (promotes); ceRNA regulation (other); other pathway/process (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Luciferase Reporter Assay; Western Blot; Transfection; MTT; Annexin V/PI Flow Cytometry; Flow Cytometry（Non-apoptosis/cycle）; Bioinformatics Analysis |
| Clinical significance: |
CircBCAR3-miR-27a-3p-SLC7A11 axis might have the potential of being a candidate target for targeted therapy in B-PLL patients. |
| Description: |
CircBCAR3 is up-regulated in the human B-prolymphocytic leukaemia cell line JVM-2 compared with normal B lymphocytes. It acts as a sponge for miR-27a-3p and positively regulates SLC7A11, thereby inhibiting ferroptosis and peroxidative damage while promoting B-PLL cell survival. |
| Confidence score: |
0.5607 |