| Expression pattern: |
DN |
| Associated gene: |
CCL5, INSC, SLC9A1, SLC34A1, EFNA5 |
| Associated microRNA: |
hsa-miR-614, hsa-miR-645, hsa-miR-4689 |
| Biological function: |
Potential tumor-suppressive circRNA reduced in colorectal cancer spheroids and metastatic lesions; predicted upstream regulator of oncogenic miRNAs and downstream tumor-suppressive genes involved in cancer stemness and CRC progression. |
| Molecular mechanism: |
Predicted circRNA-miRNA-mRNA regulatory network/ceRNA mechanism involving oncogenic miRNAs and downstream tumor-suppressive targets; hsa_circ_0039776 is proposed to regulate the hsa-miR-645-EFNA5 axis. |
| Biological pathway or process: |
ceRNA regulation (other); apoptosis (promotes); proliferation (inhibits); stemness (inhibits); metastasis (inhibits); JAK/STAT (other); cell cycle (other); other pathway/process (other) |
| Detected method: |
S
|
| Validation methods: |
RNase R Treatment; circRNA-seq; Bioinformatics Analysis; Clinical Sample Validation; Survival Analysis |
| Clinical significance: |
Potential diagnostic biomarker and therapeutic target in colorectal cancer; stepwise loss from normal colon mucosa to primary CRC and hepatic metastases suggests relevance to tumor progression. |
| Description: |
hsa_circ_0039776 was identified as a potential tumor-suppressive circRNA that is reduced in CRC spheroids and metastatic lesions, with stepwise loss from normal mucosa to primary CRC and hepatic metastases. The study proposes that it acts through a circRNA-miRNA-mRNA network, especially the hsa_circ_0039776-hsa-miR-645-EFNA5 axis, to modulate CRC progression and cancer stemness. |
| Confidence score: |
0.5746 |