| Expression pattern: |
UP |
| Associated gene: |
AK2, Ago2 |
| Associated microRNA: |
miR-141-3p |
| Biological function: |
promotes malignant behavior (proliferation, migration, invasion) and inhibits apoptosis in breast cancer cells; supports tumor growth in vivo |
| Molecular mechanism: |
ceRNA-like mechanism where circ_0075943 binds miR-141-3p and indirectly upregulates AK2 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; MTT; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry) |
| Clinical significance: |
circ_0075943 may be adopted as a new type of potential biomarker or cancer treatment earmark |
| Description: |
circ_0075943 is up-regulated in breast cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes breast cancer cell proliferation, migration and invasion while inhibiting apoptosis, and it supports tumor growth in vivo by sponging miR-141-3p to derepress AK2 (circ_0075943/miR-141-3p/AK2 axis). |
| Confidence score: |
0.7554 |