circRNA basic information
circBase ID: hsa_circ_0006990
Name: hsa_circ_VAPA
Synonym: hsa_circRNA_0006990
Host Gene: VAPA
Genomic location(hg19): chr18:9931806-9937063:+
Genomic location(hg38): chr18:9931809-9937066:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum
Cell lines:

A549
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
S
Validation methods:

divergent primers PCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

hsa_circRNA_0006990 is significantly up-regulated in the serum of NSCLC patients compared to healthy volunteers.
Description:

hsa_circ_0006990 (from host gene VAPA) is up-regulated in serum of NSCLC patients versus healthy volunteers and is highlighted as a key circRNA in the TCGA/GEO-derived circRNA network analysis. This study did not report a significant RT-qPCR expression change for hsa_circ_0006990 in PD-treated A549 cells.
Confidence score:

0.5297
Other information
Title:

Whole Transcriptome Analysis Identifies Platycodin D-Mediated RNA Regulatory Network in Non-Small-Cell Lung Cancer.

Journal: Cells
Published: 2022
PubMed ID: 35954204
Study type:

combined biological and clinical study
Data availability: Please contact the corresponding author for all data requests.
Code availability: -