| Expression pattern: |
DN |
| Associated gene: |
BMPR1B |
| Associated microRNA: |
hsa-mir-4705 |
| Biological function: |
Tumor suppressor role is proposed; down-regulation is suggested to facilitate gastric cancer progression via the hsa_circ_0067934/hsa-mir-4705/BMPR1B axis. |
| Molecular mechanism: |
ceRNA (miRNA sponging) mechanism: hsa_circ_0067934 sponges hsa-mir-4705 to regulate BMPR1B; implicated in Hippo pathway and signaling pathways regulating pluripotency of stem cells. |
| Biological pathway or process: |
Hippo/YAP (other); signaling pathways regulating pluripotency of stem cells (other); Wnt/beta-catenin (other) |
| Detected method: |
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RNA-seq |
| Clinical significance: |
Might be a novel biomarker and therapeutic target in gastric cancer; could assist diagnosis of early-stage gastric cancer (proposed). |
| Description: |
hsa_circ_0067934 was identified as down-regulated in gastric cancer from integrated GEO microarray datasets. The study proposes a ceRNA axis where hsa_circ_0067934 sponges hsa-mir-4705 to regulate BMPR1B, potentially impacting Hippo signaling and stem-cell pluripotency-related pathways, with suggested biomarker/therapeutic relevance, but without experimental wet-lab validation. |
| Confidence score: |
0.2465 |