circRNA basic information
circBase ID: hsa_circ_0001020
Name: hsa_circ_UGP2
Synonym: circ_0001020
Host Gene: UGP2
Genomic location(hg19): chr2:64083439-64085070:+
Genomic location(hg38): chr2:63856305-63857936:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0000831
MONDO name: thrombotic disease
Disease details: lower extremity deep vein thrombosis
Disease DO ID:
 0060903
Disease MeSH ID:
 D013927
Disease NCIt ID:
 C26891
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

human peripheral blood; mouse IVC tissues; lower limb venous; venous tissues
Cell lines:

-
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
UP
Associated gene: MDM2
Associated microRNA: miR-29c-3p
Biological function: hsa_circ_0001020 accelerates DVT formation and inhibits EPC migration, invasion, angiogenesis, and tube formation; hsa_circ_0001020 knockdown suppresses thrombosis and promotes EPC homing into thrombi.
Molecular mechanism: hsa_circ_0001020 functions as a ceRNA sponge for miR-29c-3p, thereby promoting MDM2 expression and inhibiting EPC migration, invasion, and angiogenesis in DVT.
Biological pathway or process:

ceRNA regulation (other); migration (inhibits); invasion (inhibits); angiogenesis (inhibits); other pathway/process (promotes)
Detected method:
Q
H
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; RNase R Treatment; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; Wound Healing Assay; Transwell Assay; Tube Formation Assay; Western Blot; IF (Immunofluorescence); In Vivo Animal Model; H&E Staining; Bioinformatics Analysis
Clinical significance:

hsa_circ_0001020 might be a potential therapeutic target and biomarker for DVT.
Description:

hsa_circ_0001020 is up-regulated in peripheral blood from DVT patients and is mainly localized in the cytoplasm of EPCs. It promotes DVT progression by sponging miR-29c-3p to increase MDM2 expression, thereby inhibiting EPC migration, invasion, angiogenesis, and thrombus-resolution-related homing. Knockdown of hsa_circ_0001020 suppresses thrombosis in a DVT mouse model, suggesting therapeutic potential.
Confidence score:

0.8108
Other information
Title:

Hsa_circ_0001020 accelerates the lower extremity deep vein thrombosis via sponging miR-29c-3p to promote MDM2 expression.

Journal: Thrombosis research
Published: 2022
PubMed ID: 35066205
Study type:

combined biological and clinical study
Data availability: Supplementary file 1; Supplementary files 2-3; https://doi.org/10.1016/j.thromres.2021.12.022
Code availability: -