| Expression pattern: |
UP |
| Associated gene: |
HMGN5 |
| Associated microRNA: |
miR-577 |
| Biological function: |
promotes gastric cancer cell proliferation and suppresses apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-577 to relieve repression of HMGN5 |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Clinical Sample Validation; Transfection; MTT; Colony Formation Assay; Western Blot; Luciferase Reporter Assay; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
high expression of circRNA_101996 was associated with larger tumor sizes |
| Description: |
In gastric cancer, hsa_circRNA_101996 is up-regulated and promotes cell proliferation while inhibiting apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-577, thereby increasing HMGN5 expression and enhancing tumor growth in a nude-mouse xenograft model. |
| Confidence score: |
0.6815 |