| Expression pattern: |
UP |
| Associated gene: |
RNF38, Smad2/3, p-Smad2/3 |
| Associated microRNA: |
miR-449a |
| Biological function: |
circ_LRIG3 promotes HCC cell proliferation, migration, invasion and tumor growth, and inhibits apoptosis; circ_LRIG3 knockdown suppresses malignant HCC phenotypes in vitro and in vivo. |
| Molecular mechanism: |
circ_LRIG3 acts as a ceRNA by sponging miR-449a to positively regulate RNF38 expression, thereby promoting the Smad2/3 pathway in HCC. |
| Biological pathway or process: |
TGF-beta/SMAD (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; Transfection; Colony Formation Assay; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circ_LRIG3 is up-regulated in HCC tissues and cell lines and functions as a tumor promoter. Its knockdown inhibits proliferation, migration, invasion, EMT-related marker changes, Smad2/3 pathway activation, and xenograft tumor growth while promoting apoptosis. Mechanistically, circ_LRIG3 sponges miR-449a to increase RNF38 expression and activate the miR-449a/RNF38/Smad2/3 axis. |
| Confidence score: |
0.7595 |