circRNA basic information
circBase ID: -
Name: hsa_circ_VAPA
Synonym: circVAPA
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

BEL-7402; HepG2; SMMC-7721; Huh7; L02
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: PSAP
Associated microRNA: miR-377-3p
Biological function: promotes HCC cell proliferation
Molecular mechanism: circVAPA promotes HCC cell proliferation via sponging miR-377-3p and thereby disinhibiting PSAP
Biological pathway or process:

proliferation (promotes); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection; CCK8; Colony Formation Assay; EdU Staining; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

potential prognostic marker of HCC patients and a novel target for HCC therapy; potential biomarker for HCC diagnosis and a promising target for HCC treatment
Description:

circVAPA is up-regulated in human HCC cell lines and promotes HCC cell proliferation. Mechanistically, circVAPA mainly localizes in the cytoplasm, sponges miR-377-3p, and relieves miR-377-3p-mediated suppression of PSAP, suggesting potential diagnostic or therapeutic relevance in HCC.
Confidence score:

0.5979
Other information
Title:

Circular RNA circVAPA Promotes Cell Proliferation in Hepatocellular Carcinoma.

Journal: Human gene therapy. Clinical development
Published: 2019
PubMed ID: 31368365
Study type:

biological research
Data availability: -
Code availability: -