circRNA basic information
circBase ID: hsa_circ_0010220
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma / OS
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: FAM98A, COL1A1, RAN, HNRNPA2B1
Associated microRNA: hsa-miR-326, hsa-miR-338-3p, hsa-miR-324-5p
Biological function: candidate serum biomarker for OS diagnosis and metastatic prediction
Molecular mechanism: ceRNA network involving one circRNA, three miRNAs and four mRNAs associated with immune cell infiltration
Biological pathway or process:

ceRNA regulation (other); immune regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Down-regulated in OS serum and included in a diagnostic model for OS with AUC 0.928
Description:

hsa-circ-0010220 is down-regulated in osteosarcoma patient serum and was proposed as a serum diagnostic biomarker. It is part of an immune cell infiltration-associated ceRNA network (circRNA-miRNA-mRNA) used to build a combined diagnostic model (AUC 0.928).
Confidence score:

0.5047
Other information
Title:

Identification of key serum biomarkers for the diagnosis and metastatic prediction of osteosarcoma by analysis of immune cell infiltration.

Journal: Cancer cell international
Published: 2022
PubMed ID: 35151325
Study type:

combined biological and clinical study
Data availability: GSE140256; GSE65071; GSE16088; GSE21257; GSE33382; GSE124768
Code availability: -