| Expression pattern: |
UP |
| Associated gene: |
IGF2BP1, MYC, JUNB, CTCF, AGO2 |
| Associated microRNA: |
miR-31-5p, miR-27b-3p |
| Biological function: |
promotes breast cancer cell migration and invasion; promotes metastasis; oncogenic role |
| Molecular mechanism: |
circRRM2 acts as a ceRNA sponge for miR-31-5p and miR-27b-3p to upregulate IGF2BP1; IGF2BP1 interacts with MYC (transcription factor) to increase circRRM2, forming a positive feedback loop |
| Biological pathway or process: |
migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; divergent primers PCR; Sanger Sequencing; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RIP (RNA Immunoprecipitation); Co-IP; Transfection; Transwell Assay; Wound Healing Assay; Western Blot; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
High circRRM2 was significantly associated with advanced N stage in patients with BC. |
| Description: |
circRRM2 (hsa_circ_0052582) is up-regulated in breast cancer tissues/cell lines and promotes migration and invasion. It functions as a ceRNA sponging miR-27b-3p and miR-31-5p to increase IGF2BP1, and IGF2BP1 interacts with MYC to enhance circRRM2 transcription, forming a positive feedback loop that supports metastasis. |
| Confidence score: |
0.8208 |