| Expression pattern: |
UP |
| Associated gene: |
CPEB4, AGO2 |
| Associated microRNA: |
hsa-miR-874-3p |
| Biological function: |
promotes proliferation, migration, invasion, tumour growth, metastasis and EMT in endometrial cancer |
| Molecular mechanism: |
ceRNA mechanism: circESRP1 sponges miR-874-3p to upregulate CPEB4, thereby promoting EMT and metastasis |
| Biological pathway or process: |
EMT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RNase R Treatment; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining; Clinical Sample Validation |
| Clinical significance: |
CircESRP1 may serve as a novel biomarker for the diagnosis and prognosis of EC and may be a potential therapeutic target for EC. |
| Description: |
circESRP1 is upregulated in endometrial cancer and mainly localizes to the cytoplasm. It promotes EC cell proliferation, migration/invasion, tumour growth and EMT by acting as a ceRNA that sponges miR-874-3p to increase CPEB4 expression. |
| Confidence score: |
0.8704 |