circRNA basic information
circBase ID: -
Name: hsa_circ_EPS15
Synonym: circRNA EPS15
Host Gene: Eps15
Genomic location(hg19): chr1:51403418-51406108:-
Genomic location(hg38): chr1:50937746-50940436:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0858950
MONDO name: traumatic brain injury
Disease details: Traumatic brain injury / TBI
Disease DO ID:
 0081292
Disease MeSH ID:
 -
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

TBI tissues; adjacent brain contusion tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: FTO
Associated microRNA: hsa-miR-2682-5p
Biological function: unknown
Molecular mechanism: ceRNA network prediction (circRNA-miRNA-mRNA)
Biological pathway or process:

inflammation (other); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNase R Treatment; RNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

circRNA EPS15 is significantly up-regulated in human TBI brain tissues versus adjacent contusion tissues and was validated by RT-qPCR. The study predicts EPS15 may participate in TBI-related processes via a circRNA-miRNA-mRNA ceRNA network (predicted miRNA: hsa-miR-2682-5p), but no direct functional experiments were performed.
Confidence score:

0.5135
Other information
Title:

Expression characteristics of circular RNA in human traumatic brain injury.

Journal: Frontiers in neurology
Published: 2022
PubMed ID: 36712438
Study type:

combined biological and clinical study
Data availability: BankIt2634779: OP794505-OP79462
Code availability: -