| Expression pattern: |
UP |
| Associated gene: |
Vimentin, AGO2 |
| Associated microRNA: |
miR-30b, miR-1266, miR-6812 |
| Biological function: |
Promotes osteosarcoma cell proliferation, migration and survivability; inhibits apoptosis; promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-30b (also binds miR-1266 and miR-6812), thereby modulating Vimentin expression and promoting osteosarcoma progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); apoptosis (inhibits); metastasis (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; divergent primers PCR; Sanger Sequencing; FISH / smFISH; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; Western Blot; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
circTUBGCP3 is up-regulated in osteosarcoma tissues and cell lines and functions as an oncogenic circRNA. It predominantly localizes to the cytoplasm and promotes proliferation, migration, survivability and in vivo tumor growth by sponging miR-30b to de-repress Vimentin expression. |
| Confidence score: |
0.8351 |