| Expression pattern: |
DN |
| Associated gene: |
FBP2, PCNA, Cyclin E, MMP2, MMP9, Ki-67 |
| Associated microRNA: |
miR-1290 |
| Biological function: |
Suppresses gastric cancer cell proliferation, migration, invasion and in vivo tumor growth. |
| Molecular mechanism: |
circ_0026344 acts as a miR-1290 sponge and upregulates FBP2 expression, thereby suppressing gastric cancer progression. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; Colony Formation Assay; EdU Staining; Transwell Assay; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
May provide a new therapeutic target or strategy for gastric cancer patients. |
| Description: |
hsa_circ_0026344/circ_0026344 is down-regulated in gastric cancer tissues and cell lines. Its overexpression suppresses GC cell proliferation, migration, invasion and xenograft tumor growth by sponging miR-1290 and upregulating FBP2, suggesting potential therapeutic relevance. |
| Confidence score: |
0.7548 |