| Expression pattern: |
UP |
| Associated gene: |
SMAD3, TGFBR2 |
| Associated microRNA: |
miR-411-5p |
| Biological function: |
Promotes PCa cell proliferation, migration, and invasion. |
| Molecular mechanism: |
Acts as a miRNA sponge/ceRNA by interacting with miR-411-5p, leading to increased SMAD3 and TGFBR2 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); TGF-beta/SMAD (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Bioinformatics Analysis; Transfection; MTT; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Luciferase Reporter Assay; Western Blot; Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
circ_0001686 is up-regulated in prostate cancer tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion). Mechanistically, it interacts with miR-411-5p and increases SMAD3/TGFBR2 expression, implicating activation of the TGF-beta/SMAD axis. |
| Confidence score: |
0.6829 |