circRNA basic information
circBase ID: hsa_circ_0077837
Name: -
Synonym: circ_0077837
Host Gene: -
Genomic location(hg19): chr6:131247744-131277639:-
Genomic location(hg38): chr6:130926604-130956499:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissues; paracancerous normal tissues adjacent to tumor tissues; lung tumor tissues in mice; xenograft tumors
Cell lines:

BEAS-2B; H1650; H1975; NCI-H1359; HCC827; A549; HEK293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: APITD1
Associated microRNA: miR-1178-3p
Biological function: Inhibits cell viability/proliferation, migration and invasion; promotes apoptosis; suppresses tumor growth in vivo (tumor suppressor in NSCLC).
Molecular mechanism: Acts as a miR-1178-3p sponge (ceRNA) to relieve repression of APITD1, thereby inhibiting NSCLC malignancy.
Biological pathway or process:

proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; IHC (Immunohistochemistry); TUNEL; Western Blot
Clinical significance:

-
Description:

hsa_circ_0077837 is down-regulated in NSCLC tissues and cell lines and acts as a tumor-suppressive circRNA. It sponges miR-1178-3p to relieve repression of the downstream target APITD1, thereby inhibiting proliferation/viability, migration and invasion while promoting apoptosis, and suppressing xenograft tumor growth.
Confidence score:

0.7132
Other information
Title:

hsa_circ_0077837 Alleviated the Malignancy of Non-Small Cell Lung Cancer by Regulating the miR-1178-3p/APITD1 Axis.

Journal: Journal of oncology
Published: 2022
PubMed ID: 35310916
Study type:

combined biological and clinical study
Data availability: The datasets during and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -